Lab Publications
(* co-First authors; # co-Corresponding authors)

2024

1. RNA structure: implications in viral infections and neurodegenerative diseases
Suiru Lu*, Yongkang Tang*, Shaozhen Yin, Lei Sun#
Advanced Biotechnology, 2024 Advanced Biotechnology
RNA structure: implications in viral infections and neurodegenerative diseases

2023

1. Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon
Pujuan Deng*, Shun-Qing Tan*, Qi-Yu Yang, Liangzheng Fu, Yachao Wu, Han-Zhou Zhu, Lei Sun, Zhangbin Bao, Yi Lin, Qiangfeng Cliff Zhang, Haoyi Wang, Jia Wang#, Jun-Jie Gogo Liu#
Cell 2023 Cell
2. PrismNet: predicting protein–RNA interaction using in vivo RNA structural information
Yiran Xu*, Jianghui Zhu*, Wenze Huang*, Kui Xu, Rui Yang, Qiangfeng cliff Zhang#, Lei Sun#
Nucleic Acids Research, 2023 Nucleic Acids Research Web server
PrismNet: predicting protein–RNA interaction using in vivo RNA structural information

2022

1. Advances and opportunities in RNA structure experimental determination and computational modeling
Jinsong Zhang*, Yuhan Fei*, Lei Sun#, Qiangfeng Cliff Zhang#
Nature Methods 2022 Nature Methods
Advances and opportunities in RNA structure experimental determination and computational modeling

2021

1. In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs
Lei Sun*, Pan Li*, Xiaohui Ju*, Jian Rao*, Wenze Huang*, Shaojun Zhang, Tuanlin Xiong, Kui Xu, Xiaolin Zhou, Lili Ren, Qiang Ding#, Jianwei Wang# and Qiangfeng Cliff Zhang#
Cell 2021 Cell bioRxiv bibtex
In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs
2. Predicting dynamic cellular protein-RNA interactions using deep learning and in vivo RNA structure
Lei Sun*, Kui Xu*, Wenze Huang*, Yucheng T. Yang*, Pan Li, Lei Tang, Tuanlin Xiong and Qiangfeng Cliff Zhang#
Cell Research 2021 Cell Research bioRxiv code website bibtex
PrismNet
3. Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.
Shaojun Zhang*, Wenze Huang*, Lili Ren*, Xiaohui Ju*, Mingli Gong*，Jian Rao*, Sun Lei, Pan Li, Qiang Ding#, Jianwei Wang#, Qiangfeng Zhang#
Cell Research 2021 Cell Research

2019

1. RNA structure maps across mammalian cellular compartments.
Lei Sun*, Furqan Fazal*, Pan Li*, James P. Broughton, Byron Lee, Lei Tang, Wenze Huang, Eric T. Kool, Howard Y. Chang# and Qiangfeng Cliff Zhang#
Nature Structural & Molecular Biology 2019 NSMB bioRxiv News & Views by NSMB journal
structural dynamic

2018

1. Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Zhongmin Liu*, Jia Wang*, Hang Cheng*, Xin Ke*, Lei Sun, Qiangfeng Cliff Zhang, Hong-Wei Wang
Cell 2018 Cell
2. Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity.
Pan Li*, Yifan Wei*, Miao Mei*,Lei Tang*, Lei Sun, Wenze Huang, Jianyu Zhou, Chunlin Zou, Shaojun Zhang, Cheng-Feng Qin, Tao Jiang, Jianfeng Dai, Xu Tan#, Qiangfeng Cliff Zhang#
Cell Host & Microbe 2018 Cell Host & Microbe

2017

1. RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing.
Meiling Piao, Lei Sun, Qiangfeng Cliff Zhang#
Genomics Proteomics Bioinformatics 2017 Genomics Proteomics Bioinformatics